Toin H van Kuppevelt Selected Research

Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)

1/2021	Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma.
1/2018	The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion.
11/2013	Heparin increases the infectivity of Human Papillomavirus type 16 independent of cell surface proteoglycans and induces L1 epitope exposure.
10/2013	Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity.
1/2012	ScFv anti-heparan sulfate antibodies unexpectedly activate endothelial and cancer cells through p38 MAPK: implications for antibody-based targeting of heparan sulfate proteoglycans in cancer.
4/2010	Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Abeta40 (DAbeta(1-40)) are modulated by sulfate moieties of heparin.
4/2009	Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity.
6/2007	Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44.
11/2005	Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46.
3/2004	Heparan sulfate proteoglycans in glomerular inflammation.

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Toin H van Kuppevelt Research Topics

Disease

39	Neoplasms (Cancer) 01/2021 - 06/2003
11	Proteinuria 01/2018 - 08/2006
9	Ovarian Neoplasms (Ovarian Cancer) 04/2017 - 10/2007
8	Albuminuria 01/2021 - 08/2006
6	Wounds and Injuries (Trauma) 08/2021 - 01/2005
6	Neoplasm Metastasis (Metastasis) 03/2020 - 03/2004
6	Carcinoma (Carcinomatosis) 04/2017 - 10/2007
6	Diabetic Nephropathies (Diabetic Nephropathy) 11/2016 - 08/2006
5	Carcinogenesis 04/2015 - 05/2010
5	Pathologic Processes 11/2014 - 05/2010
5	Inflammation (Inflammations) 01/2012 - 03/2004
4	Fibrosis (Cirrhosis) 08/2021 - 01/2015
4	Glomerulonephritis 01/2021 - 04/2007
4	Emphysema 01/2021 - 01/2003
4	Cicatrix (Scar) 05/2017 - 04/2004
4	Melanoma (Melanoma, Malignant) 09/2010 - 06/2003
3	Infections 01/2022 - 11/2013
3	Alzheimer Disease (Alzheimer's Disease) 05/2012 - 10/2008
3	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 04/2008 - 04/2004
2	Hypoxia (Hypoxemia) 01/2021 - 01/2005
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021 - 08/2006
2	Spinal Dysraphism (Spina Bifida) 01/2021 - 05/2010
2	Diaphragmatic Hernia 11/2018 - 07/2013
2	Glioblastoma (Glioblastoma Multiforme) 01/2018 - 01/2012
2	Hypertrophy 03/2016 - 04/2014
2	Mucopolysaccharidoses 01/2016 - 03/2011
2	Mucopolysaccharidosis I (Hurler Syndrome) 01/2016 - 12/2014
2	Hepatocellular Carcinoma (Hepatoma) 04/2015 - 05/2010
2	Breast Neoplasms (Breast Cancer) 01/2015 - 02/2010
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2015 - 07/2007
2	Bladder Exstrophy (Exstrophy, Bladder) 09/2014 - 01/2008
2	Gastroschisis 03/2013 - 12/2008
2	Amyloid Plaque 05/2012 - 12/2010
2	Amyloidosis 12/2010 - 10/2008
2	False Aneurysm (Pseudoaneurysm) 11/2010 - 07/2010
2	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 04/2010 - 02/2010
2	Adenocarcinoma 07/2009 - 10/2007
2	Nevus (Nevi) 03/2004 - 06/2003
1	Pain (Aches) 01/2022
1	Bites and Stings (Sting) 01/2021

Drug/Important Bio-Agent (IBA)

30	Heparitin Sulfate (Heparan Sulfate)IBA 01/2022 - 06/2003
18	GlycosaminoglycansIBA 01/2017 - 06/2003
15	Chondroitin Sulfates (Chondroitin Sulfate)IBA 03/2020 - 06/2003
14	CollagenIBA 01/2021 - 04/2004
14	EpitopesIBA 03/2016 - 06/2003
13	AntibodiesIBA 01/2021 - 06/2003
12	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2003
12	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021 - 06/2003
10	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 01/2021 - 03/2004
9	Heparin (Liquaemin)FDA LinkGeneric 11/2013 - 11/2005
8	EnzymesIBA 12/2015 - 10/2007
7	Polysaccharides (Glycans)IBA 03/2016 - 08/2006
7	Dermatan SulfateIBA 07/2015 - 12/2008
6	Proteoglycans (Proteoglycan)IBA 01/2021 - 04/2008
5	Pharmaceutical PreparationsIBA 01/2018 - 05/2014
5	Biomarkers (Surrogate Marker)IBA 01/2017 - 10/2012
5	heparanaseIBA 12/2016 - 12/2007
4	CytokinesIBA 01/2021 - 06/2003
4	LigandsIBA 01/2018 - 11/2005
4	AlbuminsIBA 04/2017 - 12/2012
3	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 08/2021 - 12/2007
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2021 - 10/2007
3	LipidsIBA 01/2021 - 02/2009
3	ChemokinesIBA 01/2021 - 03/2004
3	Biological ProductsIBA 01/2016 - 01/2003
3	Syndecan-1 (Syndecan 1)IBA 10/2015 - 02/2008
3	ChondroitinIBA 07/2015 - 06/2003
3	Sulfates (Sulfates, Inorganic)IBA 06/2010 - 08/2006
3	Amyloid beta-PeptidesIBA 04/2010 - 10/2008
2	InterferonsIBA 01/2021 - 02/2009
2	DecorinIBA 01/2021 - 07/2009
2	Immunoglobulin G (IgG)IBA 01/2021 - 05/2014
2	Matrix Metalloproteinases (MMPs)IBA 01/2019 - 04/2016
2	Streptozocin (Streptozotocin)FDA Link 11/2016 - 03/2016
2	CreatinineIBA 03/2016 - 02/2014
2	PolymersIBA 01/2016 - 07/2009
2	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2015 - 12/2012
2	Periodic AcidIBA 12/2014 - 01/2005
2	Peptides (Polypeptides)IBA 05/2012 - 04/2010
2	Amyloid (Amyloid Fibrils)IBA 05/2012 - 01/2012
2	Racemases and Epimerases (Epimerases and Racemases)IBA 03/2011 - 07/2009
2	Collagen Type I (Type I Collagen)IBA 11/2010 - 07/2009
2	Transforming Growth Factor beta (TGF-beta)IBA 08/2009 - 01/2005
2	Fibrillin-1IBA 08/2009 - 03/2008
2	Heparinoids (Heparinoid)IBA 02/2008 - 04/2007
2	AcidsIBA 12/2007 - 03/2007
2	tenascin XIBA 02/2005 - 04/2004
1	NeuropeptidesIBA 01/2022
1	Calcitonin Gene-Related PeptideIBA 01/2022
1	ONO 1301IBA 08/2021
1	4- ((4- (((4- amino- 2,3,5,6- tetramethylanilino)acetyl)(methyl)amino)- 1- piperidinyl)methyl)benzamideIBA 08/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	NectinsIBA 01/2021
1	Glycoproteins (Glycoprotein)IBA 01/2021
1	Antiviral Agents (Antivirals)IBA 01/2021
1	Differentiation AntigensIBA 01/2021
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2021

Therapy/Procedure

10	Therapeutics 01/2019 - 08/2006
3	Drug Therapy (Chemotherapy) 01/2018 - 01/2015
2	Artificial Skin 08/2021 - 05/2017